Strehl, E. and Kees, Frieder (2000) Pharmacological properties of parenteral cephalosporins - Rationale for ambulatory use. DRUGS, 59. pp. 9-18. ISSN 0012-6667
Full text not available from this repository.Abstract
Parenteral cephalosporins are among the most frequently used antibiotics in hospital therapy. They are characterised by an extended spectrum of activity against Gram-positive and Gram-negative bacteria, and some also have good activity against anaerobes. They kill proliferating bacterial cells rapidly, and generally show only a low tendency to select resistant mutants. However, there are cephalosporin compounds which induce cephalosporinases very rapidly in certain microorganisms. Together with other p-lactam antibiotics, parenteral cephalosporins interfere with bacterial cell wall synthesis by inhibiting peptido-glycan cross-linkage Because of this specific target, they are nontoxic to mammalian cells, and have a very favourable adverse effect profile. The chemical stability of parenteral cephalosporins in aqueous solution is good. After intravenous injection, high concentrations of these agents are achieved in serum and tissue. Most cephalosporins are eliminated unchanged via the kidney, with a half-life of 1 to 2 hours. But there are also derivatives with a serum half-life of more than 2 and up to 8 hours, allowing 12- or 24-hour dosage intervals. Because of their reliable efficacy and low risk of adverse effects, the parenteral cephalosporins offer a high degree of tolerability even in the setting of outpatient antibiotic therapy. In particular, the derivatives of the third generation are characterised by unique pharmacological properties.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3RD GENERATION CEPHALOSPORINS; DRUG-DELIVERY DEVICE; 3RD-GENERATION CEPHALOSPORINS; BACTERIAL-INFECTIONS; CEFTRIAXONE; PHARMACOKINETICS; SELECTION; THERAPY; PENETRATION; MULTICENTER; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2021 05:59 |
| Last Modified: | 28 Apr 2021 05:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42943 |
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