Buechler, Christa and Ritter, Mirko and Orso, Evelyn and Langmann, Thomas and Klucken, Jochen and Schmitz, Gerd (2000) Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. JOURNAL OF LEUKOCYTE BIOLOGY, 67 (1). pp. 97-103. ISSN 0741-5400
Full text not available from this repository. (Request a copy)Abstract
CD163, also referred to as M130, member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14(bright) CD16(+) monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony-stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes, In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-P) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), and tumor necrosis factor alpha, whereas IL-6 and the antiinflammatory cytokine interleukin-10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophage. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels, Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators, This expression pattern implies a functional role of CD163 in the antiinflammatory response of monocytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEMBRANE-PROTEIN RM3/1; LYMPHOMA CELL LINES; MONOCLONAL-ANTIBODY; DIFFERENTIATION ANTIGEN; MESSENGER-RNA; ENDOTHELIAL-CELLS; LPS; IL-10; IDENTIFICATION; MEMBER; interleukin-10; interferon-gamma; inflammation; tumor necrosis factor alpha |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2022 12:13 |
| Last Modified: | 07 Jun 2022 12:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43013 |
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