Hemauer, Andrea and Gigler, Andreas and Searle, Karen and Beckenlehner, Karin and Raab, Ulla and Broliden, Kristina and Wolf, Hans and Enders, Gisela and Modrow, Susanne (2000) Seroprevalence of parvovirus B19NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women. JOURNAL OF MEDICAL VIROLOGY, 60 (1). pp. 48-55. ISSN 0146-6615
Full text not available from this repository. (Request a copy)Abstract
Parvovirus B19 is the causative agent of erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. These include acute and chronic arthritis, hydrops fetalis in pregnant women, aplastic anemia, and thrombocytopenia. The host's immune response is directed against the viral structural proteins VP1 and VP2. This study investigated the presence of IgG against the viral nonstructural protein NS1 using Western blot. Serum panels from healthy individuals, B19-infected pregnant women, and various disease groups were tested. The disease groups included patients with symptoms that may be linked to parvovirus B19 infection. The results showed that IgG against the NS1 protein was present in 22% of healthy individuals with past B19 infection. In cases of persistent or prolonged B19 infections, the prevalence of NS1-specific antibodies was as high as 80%. It is concluded that NS1-specific IgG may be used as an indicator of chronic or more severe courses of parvovirus B19 infections. J. Med. Virol. 60:48-55, 2000. (C) 2000 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC LUPUS-ERYTHEMATOSUS; INFECTIOSUM 5TH DISEASE; B19 INFECTION; NONSTRUCTURAL PROTEIN; RHEUMATOID-ARTHRITIS; SYNOVIAL MEMBRANES; HYDROPS-FETALIS; APLASTIC CRISIS; CAUSATIVE AGENT; BONE-MARROW; parvovirus B19; NS1-specific antibodies; antibody prevalence; hydrops fetalis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2022 12:17 |
| Last Modified: | 07 Jun 2022 12:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43014 |
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