Grundmann-Kollmann, Marcella and Behrens, Stefanie and Gruss, Claus and Gottloeber, Petra and Peter, Ralf Uwe and Kerscher, Martina (2000) Chronic sclerodermic graft-versus-host disease refractory to immunosuppressive treatment responds to UVA(1) phototherapy. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 42 (1). pp. 134-136. ISSN 0190-9622
Full text not available from this repository.Abstract
Graft-versus-host disease is a frequent complication of allogenic bone marrow transplantation. Approximately 10% of patients suffering from chronic graft-versus-host disease develop sclerodermic graft-versus-host disease of the skin, which often does not respond to conventional immunosuppressive therapy. An alternative to immunosuppressive treatment is photochemotherapy. We describe a patient with chronic sclerodermic graft-versus-host disease who did not respond to a combination therapy of cyclosporine and prednisone and later mycophenolate mofetil plus prednisone. A combination therapy of mycophenolate mofetil (2 g/day) and low-dose UVA(1) therapy (single dose, 20 J/cm(2), 4 times per week over 6 weeks) resulted in striking clinical improvement of sclerodermic graft-versus-host disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOCALIZED SCLERODERMA; COLLAGENASE; FIBROBLASTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jun 2022 07:05 |
| Last Modified: | 08 Jun 2022 07:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43024 |
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