Ittner, K. P. and Zimmermann, M. and Bucher, M. and Gessele, W. and Kees, Frieder and Krämer, B. K. and Grobecker, H. F. (2000) The effect of urapidil and ramipril on hyperglycemia in streptozotocin diabetic rats. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 361 (1). pp. 92-97. ISSN 0028-1298
Full text not available from this repository.Abstract
Angiotensin-converting enzyme inhibitors and alpha(1)-adrenoceptor antagonists improve glucose disposal in diabetes mellitus. We compared the effect of the antihypertensive hybrid drug urapidil [alpha(1)-adrenoceptor antagonist serotonin 1A (5-hydroxytryptamine 1A, 5-HT1A) receptor agonist] on hyperglycemia in streptozotocin diabetic rats with the angiotensin-converting enzyme inhibitor ramipril. 5-HT1A receptor agonists induce hyper-glycemia. This could be an important disadvantage during hypertension occurs in both forms of diabetes introduction treatment of diabetes mellitus with urapidil. Diabetes was induced by streptozotocin (70 mg/kg i.p.). Treatment for 7 days (ramipril 10 mg/kg p.o.; urapidil 20 mg/kg p.o.) significantly decreased mean blood glucose values (urapidil: 15.7+/-0.9 mmol/l, P=0.007; ramipril: 15.0+/-0.8 mmol/l, P=0.038 vs. diabetic control group: 18.7+/-1.0 mmol/l). Both drugs reduced significantly blood pressure, urinary glucose, water consumption, and food requirement. Serotonin concentration in the brain (medulla oblongata, pituitary) was not affected. A normalization comparable with healthy control rats was observed only in a diabetic control group with insulin therapy. In conclusion, our results demonstrate that the antihypertensive drug urapidil has no detrimental effect on hyperglycemia compared with the angiotensin-converting enzyme inhibitor ramipil in experimental diabetes mellitus despite its 5-HT1A receptor agonistic properties.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-RESISTANCE; 5-HT1A RECEPTORS; MELLITUS; PERFORMANCE; INHIBITION; SYSTEM; BRAIN; diabetes-mellitus; streptozotocin; angiotensin-converting enzyme inhibitors ramipril; adrenergic alpha(1)-antagonists; 5-hydroxytryptamine(1A) receptor; urapidil |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Jul 2022 09:55 |
| Last Modified: | 01 Jul 2022 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43039 |
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