Crossland, Rachel E. and Perutelli, Francesca and Bogunia-Kubik, Katarzyna and Mooney, Nuala and Gasperov, Nina Milutin and Pucic-Bakovic, Maja and Greinix, Hildegard and Weber, Daniela and Holler, Ernst and Pulanic, Drazen and Wolff, Daniel and Dickinson, Anne M. and Inngjerdingen, Marit and Grce, Magdalena (2020) Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease. FRONTIERS IN IMMUNOLOGY, 11: 602547. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
Prognostic, diagnostic or predictive biomarkers are urgently needed for assessment of chronic graft-versus-host disease (cGvHD), a major risk for patients undergoing allogeneic hematopoietic stem cell transplantation. The main goal of this review generated within the COST Action EUROGRAFT "Integrated European Network on Chronic Graft Versus Host Disease" was to identify potential novel biomarkers for cGvHD besides the widely accepted molecular and cellular biomarkers. Thus, the focus was on cellular biomarkers, alloantibodies, glycomics, endothelial derived particles, extracellular vesicles, microbiome, epigenetic and neurologic changes in cGvHD patients. Both host-reactive antibodies in general, and particularly alloantibodies have been associated with cGvHD and require further consideration. Glycans attached to IgG modulate its activity and represent a promising predictive and/or stratification biomarker for cGVHD. Furthermore, epigenetic changes such as microRNAs and DNA methylation represent potential biomarkers for monitoring cGvHD patients and novel targets for developing new treatment approaches. Finally, the microbiome likely affects the pathophysiology of cGvHD; bacterial strains as well as microbial metabolites could display potential biomarkers for dysbiosis and risk for the development of cGvHD. In summary, although there are no validated biomarkers currently available for clinical use to better inform on the diagnosis, prognosis or prediction of outcome for cGvHD, many novel sources of potential markers have shown promise and warrant further investigation using well characterized, multi-center patient cohorts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONSENSUS DEVELOPMENT PROJECT; ANTI-HLA ANTIBODIES; STEM-CELL TRANSPLANTATION; REGULATORY B-CELLS; DONOR-SPECIFIC ANTIBODIES; CLINICAL-TRIALS; BRONCHIOLITIS OBLITERANS; ENDOTHELIAL-CELLS; CHRONIC GVHD; T-CELLS; chronic graft-versus-host disease (cGvHD); alloantibodies; glycomics; endothelial derived particles; extracellular vesicles; epigenetic changes; microbiome; cellular biomarkers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Apr 2021 09:07 |
| Last Modified: | 20 Apr 2021 09:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43095 |
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