Palazzo, Ottavia and Rass, Mathias and Brembs, Bjoern (2020) Identification of FoxP circuits involved in locomotion and object fixation in Drosophila. OPEN BIOLOGY, 10 (12): 200295. ISSN , 2046-2441
Full text not available from this repository. (Request a copy)Abstract
The FoxP family of transcription factors is necessary for operant self-learning, an evolutionary conserved form of motor learning. The expression pattern, molecular function and mechanisms of action of the Drosophila FoxP orthologue remain to be elucidated. By editing the genomic locus of FoxP with CRISPR/Cas9, we find that the three different FoxP isoforms are expressed in neurons, but not in glia and that not all neurons express all isoforms. Furthermore, we detect FoxP expression in, e.g. the protocerebral bridge, the fan-shaped body and in motor neurons, but not in the mushroom bodies. Finally, we discover that FoxP expression during development, but not adulthood, is required for normal locomotion and landmark fixation in walking flies. While FoxP expression in the protocerebral bridge and motor neurons is involved in locomotion and landmark fixation, the FoxP gene can be excised from dorsal cluster neurons and mushroom-body Kenyon cells without affecting these behaviours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-EXPRESSION NOISE; SEVERE SPEECH DELAY; MUSHROOM BODIES; SINGING BEHAVIOR; CENTRAL COMPLEX; BODY; EVOLUTION; STOCHASTICITY; MELANOGASTER; ORIENTATION; FoxP; Drosophila; behavioural biology; molecular biology |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Mar 2021 13:40 |
| Last Modified: | 04 Mar 2021 13:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43126 |
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