Terhoeven, Pauline and Seybold, Julia and Utz, Kathrin S. and Nickel, Florian T. and Lee, De-Hyung and Linker, Ralf A. (2020) Longer-term effects of intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: Who benefits? JOURNAL OF THE NEUROLOGICAL SCIENCES, 419: 117169. ISSN 0022-510X, 1878-5883
Full text not available from this repository. (Request a copy)Abstract
Intravenous immunoglobulins (IVIg) represent an established cornerstone for the immunotherapy of chronic inflammatory demyelinating polyneuropathy (CIDP). Efficacy of IVIg for CIDP was proven in a large phase III trial. Yet, data on longer-term efficacy and effects in distinct subgroups are scarce. Our trial investigates the longterm efficacy of IVIg treatment in CIDP patients. In this observational real-world study, we retrospectively analyzed 49 CIDP patients receiving continuous IVIg treatment with a mean initial dosage of 87 g (1 g/kg body weight) every 4 weeks over a mean time of 45 months between 2010 and 2018. INCAT-Scores before the start of treatment and at the end of the observation period were compared. Over the observation period, IVIg treatment led to a median improvement of one INCAT score point. Subgroup analyses revealed a more pronounced improvement of INCAT scores in female CIDP patients, individuals with relapsing disease courses, patients with more pronounced motor impairment (higher initial INCAT scores) and in the cohort without need for concomitant other immunotherapies. These data argue for sustained beneficial effects of longer-term immunotherapy with IVIg in CIDP, particularly in females and relapsing disease forms with higher disease activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOLLOW-UP; POLYRADICULONEUROPATHY; IVIG; PREVALENCE; INFUSION; TRIAL; CIDP; Chronic inflammatory demyelinating polyneuropathy; Immunotherapy; Intravenous immunoglobulins; Long-term effect; Polyneuritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2021 07:46 |
| Last Modified: | 05 Mar 2021 07:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43131 |
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