Maerkl, Susanne and Schroter, Alexandra and Hirsch, Thomas (2020) Small and Bright Water-Protected Upconversion Nanoparticles with Long-Time Stability in Complex, Aqueous Media by Phospholipid Membrane Coating. NANO LETTERS, 20 (12). pp. 8620-8625. ISSN 1530-6984, 1530-6992
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Chemical and colloidal stability in complex aqueous media are among the main challenges preventing nanoparticles from successfully entering into the biomedical field. Small core-shell upconversion nanoparticles (UCNPs) NaY-F-4:Yb,E@NaYF4 of 12 nm in diameter with a high surface-to-volume ratio are utilized to demonstrate that self-assembling phospholipid bilayers (PLMs) have several benefits compared to common ligand-exchange and ligand-addition particle coatings such as poly(acrylic acid) and amphiphilic polymers. An efficient hydrophobic barrier against water quenching and toward particle disintegration is formed by PLM. Particles with this functionalization have a higher upconversion luminescence in aqueous media in contrast to common surface ligands. They attract with better colloidal stability in phosphate buffer, in a wide pH range, in high ionic solutions, and in complex cell media, as is required for biological applications. Moreover, kidney cells (NRK) are not affected by these stable PLM-coated UCNPs as first cell viability tests reveal.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NANOPHOSPHORS; CURVATURE; DESIGN; LIPIDS; Luminescence; nanoparticle; phospholipids; surface chemistry; upconversion |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2021 08:07 |
| Last Modified: | 05 Mar 2021 08:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43155 |
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