Antoni, Frauke and Bernhardt, Guenther (2021) Derivatives of nitrogen mustard anticancer agents with improved cytotoxicity. ARCHIV DER PHARMAZIE, 354 (4): e2000366. ISSN 0365-6233, 1521-4184
Full text not available from this repository. (Request a copy)Abstract
In previous studies, we demonstrated that esters of bendamustine containing a basic moiety are far more cytotoxic anticancer agents than their parent compound and that the substitution of the labile ester moiety by a branched ester or an amide markedly increases stability in the blood plasma. In the current study, we showed that this substitution was bioisosteric. Aiming at increased cytotoxicity, we introduced the same modification to related nitrogen mustards: 6-isobendamustine, chlorambucil, and melphalan. The synthesis was accomplished using the coupling reagents N,N '-dicyclohexylcarbodiimide or 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate. Cytotoxicity against a panel of diverse cancer cells (carcinoma, sarcoma, and malignant melanoma) was assessed in a kinetic chemosensitivity assay. The target compounds showed cytotoxic or cytocidal effects at concentrations above 1 mu M: a striking enhancement over bendamustine and 6-isobendamustine, both ineffective against the selected cancer cells at concentrations up to 50 mu M, and a considerable improvement over chlorambucil, showing some potency only against the sarcoma cells. Melphalan was almost as effective as the target compounds-derivatization only provided a small improvement. The novel cytostatics are of interest as model compounds for analyzing a correlation between cytotoxicity and membrane transport and for the treatment of malignancies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BENDAMUSTINE; MELPHALAN; CANCER; MECHANISM; PATTERN; PLASMA; bendamustine; chlorambucil; derivatives; melphalan; nitrogen mustards |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 13:36 |
| Last Modified: | 21 Apr 2021 13:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43168 |
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