Trpchevska, Natalia and Bulla, Jan and Hellberg, Matilda Prada and Edvall, Niklas K. and Lazar, Andra and Mehraei, Golbarg and Uhlen, Inger and Schlee, Winfried and Canlon, Barbara and Gallus, Silvano and Antonio Lopez-Escamez, Jose and Cederroth, Christopher R. (2020) Sex-Dependent Aggregation of Tinnitus in Swedish Families. JOURNAL OF CLINICAL MEDICINE, 9 (12): 3812. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Twin and adoption studies point towards a genetic contribution to tinnitus; however, how the genetic risk applies to different forms of tinnitus is poorly understood. Here, we perform a familial aggregation study and determine the relative recurrence risk for tinnitus in siblings (lambda s). Four different Swedish studies (N = 186,598) were used to estimate the prevalence of self-reported bilateral, unilateral, constant, and severe tinnitus in the general population and we defined whether these 4 different forms of tinnitus segregate in families from the Swedish Tinnitus Outreach Project (STOP, N = 2305). We implemented a percentile bootstrap approach to provide accurate estimates and confidence intervals for lambda s. We reveal a significant lambda s for all types of tinnitus, the highest found being 7.27 (95% CI (5.56-9.07)) for severe tinnitus, with a higher susceptibility in women (10.25; 95% CI (7.14-13.61)) than in men (5.03; 95% CI (3.22-7.01)), suggesting that severity may be the most genetically influenced trait in tinnitus in a sex-dependent manner. Our findings strongly support the notion that genetic factors impact on the development of tinnitus, more so for severe tinnitus. These findings highlight the importance of considering tinnitus severity and sex in the design of large genetic studies to optimize diagnostic approaches and ultimately improve therapeutic interventions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENETICALLY COMPLEX TRAITS; RECURRENCE-RISK RATIO; LINKAGE STRATEGIES; TWIN; POLYMORPHISM; PLASTICITY; DISORDER; tinnitus; familial aggregation; genetic risk; hearing loss; bilateral; unilateral; constant |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 07:35 |
| Last Modified: | 08 Mar 2021 07:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43252 |
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