Herhaus, Peter and Lipkova, Jana and Lammer, Felicitas and Yakushev, Igor and Vag, Tibor and Slotta-Huspenina, Julia and Habringer, Stefan and Lapa, Constantin and Pukrop, Tobias and Hellwig, Dirk and Wiestler, Benedikt and Buck, Andreas K. and Deckert, Martina and Wester, Hans-Juergen and Bassermann, Florian and Schwaiger, Markus and Weber, Wolfgang and Menze, Bjoern and Keller, Ulrich (2020) CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma. JOURNAL OF NUCLEAR MEDICINE, 61 (12). ISSN 0161-5505, 1535-5667
Full text not available from this repository. (Request a copy)Abstract
C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. MRI is the standard imaging technology for central nervous system (CNS) involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. Methods: In this proof-of-concept study, 11 patients with lymphoma of the CNS (8 primary and 3 secondary involvement) were imaged with the CXCR4-directed PET tracer Ga-68-pentixafor. To evaluate the predictive value of this imaging modality, treatment response, as determined by MRI, was correlated with quantification of CXCR4 expression by Ga-68-pentixafor PET in vivo before initiation of treatment in 7 of 11 patients. Results: Ga-68-pentixafor PET showed excellent contrast with the surrounding brain parenchyma in all patients with active disease. Furthermore, initial CXCR4 uptake determined by PET correlated with subsequent treatment response as assessed by MRI. Conclusion: Ga-68-pentixafor PET represents a novel diagnostic tool for CNS lymphoma with potential implications for theranostic approaches as well as response and risk assessment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY CNS LYMPHOMA; INTERNATIONAL EXTRANODAL LYMPHOMA; WHOLE-BRAIN RADIOTHERAPY; IMMUNOCOMPETENT PATIENTS; CXCR4 EXPRESSION; MULTIPLE-MYELOMA; UNITED-STATES; DIAGNOSIS; METHOTREXATE; SURVIVAL; central nervous system lymphoma; CXCR4; in vivo imaging; PET; MRI |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 07:13 |
| Last Modified: | 08 Mar 2021 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43291 |
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