Gomila, Alexandre M. J. and Rustler, Karin and Maleeva, Galyna and Nin-Hil, Alba and Wutz, Daniel and Bautista-Barrufet, Antoni and Rovira, Xavier and Bosch, Miquel and Mukhametova, Elvira and Petukhova, Elena and Ponomareva, Dania and Mukhamedyarov, Marat and Peiretti, Franck and Alfonso-Prieto, Mercedes and Rovira, Carme and Koenig, Burkhard and Bregestovski, Piotr and Gorostiza, Pau (2020) Photocontrol of Endogenous Glycine Receptors In Vivo. CELL CHEMICAL BIOLOGY, 27 (11). 1425-+. ISSN 2451-9448,
Full text not available from this repository. (Request a copy)Abstract
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 07:56 |
| Last Modified: | 08 Mar 2021 07:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43349 |
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