Bazarbachi, Abdul Hamid and Al Hamed, Rama and Labopin, Myriam and Halaburda, Kazimierz and Labussiere, Helene and Bernasconi, Paolo and Schroyens, Wilfried and Gandemer, Virginie and Schaap, Nicolaas P. M. and Loschi, Michael and Jindra, Pavel and Snowden, John and Wu, Depei and Guffroy, Blandine and Rovira, Montserrat and Chantepie, Sylvain P. and Poire, Xavier and Lopez-Corral, Lucia and Nikolousis, Manos and Pelosini, Matteo and Ciceri, Fabio and Baron, Frederic and Bazarbachi, Ali and Corbacioglu, Selim and Savani, Bipin N. and Peric, Zinaida and Nagler, Arnon and Carreras, Enric and Mohty, Mohamad (2021) Underdiagnosed veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) as a major cause of multi-organ failure in acute leukemia transplant patients: an analysis from the EBMT Acute Leukemia Working Party. BONE MARROW TRANSPLANTATION, 56. pp. 917-927. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Allogeneic hematopoietic cell transplantation (alloHCT) is a complex, potentially fatal therapy featuring a myriad of complications. Triggering event(s) of such complications vary significantly, but often a so-called "multi-organ failure" (MOF) is reported as the leading cause of death. The identification of the exact trigger of MOF is critical towards early and disease-specific intervention to improve outcome. We examined data from 202 alloHCT patients reported to have died of MOF from the EBMT registry aiming to determine their exact cause of death focusing on veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) due to its life-threatening, often difficult to capture yet preventable nature. We identified a total of 70 patients (35%) for whom VOD/SOS could be considered as trigger for MOF and leading cause of death, among which 48 (69%) were previously undiagnosed. Multivariate analysis highlighted history of hepatic comorbidity or gentuzumab use and disease status beyond CR1 as the only significant factors predictive of VOD/SOS incidence (OR = 6.6; p = 0.001 and OR = 3.3; p = 0.004 respectively). VOD/SOS-related MOF was widely under-reported, accounting for 27% of deaths attributed to MOF of unknown origin without a previous VOD/SOS diagnosis. Our results suggest most missed cases developed late VOD/SOS beyond 21 days post-alloHCT, highlighting the importance of the newly revised EBMT criteria.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; OCCLUSIVE DISEASE; MARROW-TRANSPLANTATION; CELL TRANSPLANTATION; EUROPEAN-SOCIETY; DIAGNOSIS; BLOOD; LIVER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 08:54 |
| Last Modified: | 21 Apr 2021 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43352 |
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