Graf, Marion and Boettcher, Hans-Christian and Suenkel, Karlheinz and Thavalingam, Sugina and Metzler-Nolte, Nils and Czerwieniec, Rafal (2021) Bis-cyclometalated Iridium Complexes Containing Modified Phenanthroline Ligands and Evaluation of their Cytotoxic Activities. ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 647 (4). pp. 306-311. ISSN 0044-2313, 1521-3749
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The synthesis and characterization of new bis-cyclometalated complex salts [Ir(ptpy)(2)(L-phen)]PF6 with L-phen = 2,9-dimethyl-4,7-bis(pentyloxy)-1,10-phenanthroline (1) and L-phen = 2,9-dimethyl-4,7-bis(2-ethoxyethoxyl)-1,10-phenanthroline (2) are described. Compounds 1 and 2 were obtained by the reaction of the corresponding phenanthroline ligands with [{Ir(mu-Cl)(ptpy)(2)}(2)] in a refluxing CH2Cl2/MeOH mixture. The molecular structure of compound 2 was confirmed by single-crystal X-ray structure determination. Complex 2 was crystallized from dichloromethane/methanol/iso-hexane in the monoclinic space group P2(1)/c. The biological activity of both new compounds was examined, and they exhibit significant cytotoxicity against human cancer cell lines with the IC50 values around 2 mu M, significantly better than the established anticancer drug cisplatin under identical conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; RHODIUM; BINDING; Bioorganometallic chemistry; Cyclometalated complexes; Iridium; Organometallic anticancer drugs |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Hartmut Yersin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 06:47 |
| Last Modified: | 21 Apr 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43388 |
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