Ruethrich, Maria Madeleine and Giessen-Jung, C. and Borgmann, S. and Classen, A. Y. and Dolff, S. and Gruener, B. and Hanses, F. and Isberner, N. and Koehler, P. and Lanznaster, J. and Merle, U. and Nadalin, S. and Piepel, C. and Schneider, J. and Schons, M. and Strauss, R. and Tometten, L. and Vehreschild, J. J. and von Lilienfeld-Toal, M. and Beutel, G. and Wille, K. (2021) COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry. ANNALS OF HEMATOLOGY, 100 (2). pp. 383-393. ISSN 0939-5555, 1432-0584
Full text not available from this repository. (Request a copy)Abstract
Introduction Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk. Patients and methods We retrospectively analyzed a cohort of 435 cancer patients and 2636 non-cancer patients with confirmed SARS-CoV-2 infection, enrolled between March 16 and August 31, 2020. Data on socio-demographics, comorbidities, cancer-related features and infection course were collected. Age-, sex- and comorbidity-adjusted analysis was performed. Primary endpoint was COVID-19-related mortality. Results In total, 435 cancer patients were included in our analysis. Commonest age category was 76-85 years (36.5%), and 40.5% were female. Solid tumors were seen in 59% and lymphoma and leukemia in 17.5% and 11% of patients. Of these, 54% had an active malignancy, and 22% had recently received anti-cancer treatments. At detection of SARS-CoV-2, the majority (62.5%) presented with mild symptoms. Progression to severe COVID-19 was seen in 55% and ICU admission in 27.5%. COVID-19-related mortality rate was 22.5%. Male sex, advanced age, and active malignancy were associated with higher death rates. Comparing cancer and non-cancer patients, age distribution and comorbidity differed significantly, as did mortality (14% vs 22.5%, p value < 0.001). After adjustments for other risk factors, mortality was comparable. Conclusion Comparing cancer and non-cancer patients, outcome of COVID-19 was comparable after adjusting for age, sex, and comorbidity. However, our results emphasize that cancer patients as a group are at higher risk due to advanced age and pre-existing conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MORTALITY; COVID-19; SARS-CoV-2; Cancer patients; Pandemic; LEOSS; Cohort study; Adjusted analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 06:56 |
| Last Modified: | 28 Feb 2022 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43399 |
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