Treutwein, Marius and Loeschel, Rainer and Hipp, Matthias and Koelbl, Oliver and Dobler, Barbara (2020) Secondary malignancy risk for patients with localized prostate cancer after intensity-modulated radiotherapy with and without flattening filter. JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 21 (12). pp. 197-205. ISSN 1526-9914,
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Men treated for localized prostate cancer by radiotherapy have often a remaining life span of 10 yr or more. Therefore, the risk for secondary malignancies should be taken into account. Plans for ten patients were evaluated which had been performed on an Oncentra (R) treatment planning system for a treatment with an Elekta Synergy (TM) linac with Agility (TM) head. The investigated techniques involved IMRT and VMTA with and without flattening filter. Different dose response models were applied for secondary carcinoma and sarcoma risk in the treated region and also in the periphery. As organs at risk we regarded for carcinoma risk urinary bladder, rectum, colon, esophagus, thyroid, and for sarcoma risk bone and soft tissue. The excess absolute risk (EAR) was found very similar in the treated region for both techniques (IMRT and VMAT) and also for both with and without flattening filter. The secondary sarcoma risk resulted about one magnitude smaller than the secondary carcinoma risk. The EAR to the peripheral organs was statistically significant reduced by application of the flattening filter free mode concerning the flattening filter as main source of scattered dose. Application of flattening filter free mode can thus support to reduce second malignancy risk for patients with localized prostate cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOFT-TISSUE SARCOMA; 2ND PRIMARY CANCERS; ARC THERAPY VMAT; RADIATION-THERAPY; RECTAL-CANCER; IMRT; IMPACT; PHOTON; BEAM; CARCINOMA; flattening filter free; IMRT; localized prostate cancer; secondary malignancy risk; VMAT |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 09:22 |
| Last Modified: | 08 Mar 2021 09:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43414 |
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