Treeck, Oliver and Schueler-Toprak, Susanne and Ortmann, Olaf (2020) Estrogen Actions in Triple-Negative Breast Cancer. CELLS, 9 (11): 2358. ISSN 2073-4409
Full text not available from this repository. (Request a copy)Abstract
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) alpha, but the expression of estrogen receptors ER beta and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-related receptors (ERRs). In this review article, we discuss the role of ER beta and GPER-1 as mediators of E2 action in TNBC as well as the function of ERRs as activators and modulators of estrogen signaling in this cancer entity. For this purpose, original research articles on estrogen actions in TNBC were considered, which are listed in the PubMed database. Additionally, we performed meta-analyses of publicly accessible integrated gene expression and survival data to elucidate the association of ER beta, GPER-1, and ERR expression levels in TNBC with survival. Finally, options for endocrine therapy strategies for TNBC were discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-COUPLED RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; GENE-EXPRESSION; ERR-ALPHA; INVERSE AGONIST; BETA EXPRESSION; TARGET GENES; CELLS; GPER; triple-negative breast cancer; estrogen; estrogen receptor; G-protein coupled estrogen receptor 1; estrogen-related receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 05:01 |
| Last Modified: | 21 Apr 2021 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43459 |
Actions (login required)
 |
View Item |
