Huelsen, Sabine and Lippolis, Eleonora and Ferrazzi, Fulvia and Otto, Wolfgang and Distel, Luitpold and Fietkau, Rainer and Denzinger, Stefan and Breyer, Johannes and Burger, Maximilian and Bertz, Simone and Eckstein, Markus and Ebner, Annette and Hartmann, Arndt and Geppert, Carol I. (2020) High Stroma T-Cell Infiltration is Associated with Better Survival in Stage pT1 Bladder Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (21): 8407. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Stage pT1 bladder cancer (BC) shows highly diverse outcomes. Predictive markers are required to stratify patients for personalized treatment. The present study aimed to validate immune response quantification as a prognostic marker. Patients with pT1 BC (n = 167) treated by transurethral resection of the bladder (TURB) were enrolled. Formaldehyde-fixed paraffin-embedded material was stained for CD3 and CD8. Corresponding T cells were counted in three regions with the highest immune response. Numbers of tertiary lymphoid structures (TLS) and lymphocyte aggregates (LA) were quantified. High CD3(+) stroma T-cell infiltration was associated with improved survival (p = 0.045), especially in the G3 subgroup (p = 0.01). Cluster with higher immune response showed less recurrence (p = 0.034) and favorable overall survival (OS) (p = 0.019). In contrast, higher CD3(+) and CD8(+) tumor T-cell infiltration seemed to have a negative impact on prognosis. TLS and LA were more frequently observed in G3 tumors, indicating an increased anti-tumoral immune response. We proved the role of immune cell infiltration and showed that higher infiltration numbers of CD3(+) (not CD8(+)) lymphocytes in the stroma are associated with favorable outcome. Immune cell quantification could be used as a marker to help stratify patients' risk and therefore, to optimize patients' management and follow-up examination as well as possible therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGRESSION; LYMPHOCYTES; CARCINOMA; TUMORS; pT1 bladder cancer; immunoscore; tumor-infiltrating lymphocytes (TILs); CD3(+) lymphocytes; CD8(+) lymphocytes; progression; survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 13:25 |
| Last Modified: | 08 Mar 2021 13:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43474 |
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