Levine, Seth M. and Kumpf, Miriam and Rupprecht, Rainer and Schwarzbach, Jens (2021) Supracategorical fear information revealed by aversively conditioning multiple categories. COGNITIVE NEUROSCIENCE, 12 (1). pp. 28-39. ISSN 1758-8928, 1758-8936
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Fear-generalization is a critical function for survival, in which an organism extracts information from a specific instantiation of a threat (e.g., the western diamondback rattlesnake in my front yard on Sunday) and learns to fear - and accordingly respond to - pertinent higher-order information (e.g., snakes live in my yard). Previous work investigating fear-conditioning in humans has used functional magnetic resonance imaging (fMRI) to demonstrate that activity patterns representing stimuli from an aversively-conditioned category (CS+) are more similar to each other than those of a neutral category (CS-). Here we used fMRI and multiple aversively-conditioned categories to ask whether we would find only similarity increases within the CS+ categories or also similarity increases between the CS+ categories. Using representational similarity analysis, we correlated several models to activity patterns underlying different brain regions and found that, following fear-conditioning, between-category and within-category similarity increased for the CS+ categories in the insula, superior frontal gyrus (SFG), and the right temporal pole. When specifically investigating fear-generalization, these between- and within-category effects were detected in the SFG. These results advance prior pattern-based neuroimaging work by exploring the effect of aversively-conditioning multiple categories and indicate an extended role for such regions in potentially representing supracategorical information during fear-learning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LONG-TERM-MEMORY; ANTERIOR INSULA; BRAIN ACTIVITY; ACTIVATION; EMOTION; FMRI; REPRESENTATIONS; EXPERIENCE; SIMILARITY; PATTERNS; Aversive-learning; fear-generalization; fMRI; multivariate pattern analysis; representational similarity analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2021 16:44 |
| Last Modified: | 17 May 2021 16:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43481 |
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