Pfluecke, C. and Wydra, S. and Berndt, K. and Tarnowski, D. and Cybularz, M. and Jellinghaus, S. and Mierke, J. and Ende, G. and Poitz, D. M. and Barthel, P. and Heidrich, F. M. and Quick, S. and Sveric, K. M. and Speiser, U. and Linke, A. and Ibrahim, K. (2020) Mon2-monocytes and increased CD-11b expression before transcatheter aortic valve implantation are associated with earlier death. INTERNATIONAL JOURNAL OF CARDIOLOGY, 318. pp. 115-120. ISSN 0167-5273, 1874-1754
Full text not available from this repository. (Request a copy)Abstract
Background: In the first three months after Transcatheter aortic valve implantation (TAVI), a remarkable number of patients have an unfavorable outcome. An inflammatory response after TAVI is suspected to have negative effects. The exact mechanisms remain unclear. We examined the influence of monocyte subpopulations on the clinical outcome, along with the degree of monocyte activation and further parameters of inflammation and platelet activation. Methods: Flow-cytometlic quantification analyses of peripheral blood were done in 120 consecutive patients who underwent TAVI (one day before TAVI and on day 1 and 7 after TAVI). Monocyte-subsets were defined by their CD14 and CD16 expression, monocyte-platelet-aggregates (MPA) by CD14/CD41 co-ex pression. The extent of monocyte activation was determined by quantification of CD11b-expression (activation epitope). Additionally, pro-inflammatoiy cytokines such as interleukin (IL)-6, IL-8, C-reactive protein were measured with the cytometric bead array method or standard laboratory tests. Results: Elevated Mon2 (CD14(-+)CD16(+)) - monocytes (38 vs. 62 cells/mu l, p < 0.001) and a high expression of CD11b prior to TAVI (MIL 50.1 vs. 84.6, p < 0.05) were independently associated with death 3 months after TAVI. Mon2 showed the highest CD11b-expression and CD11b correlated with platelet activation and markers of systemic inflammation. Even CRP and IL-8 before TAVI were associated with death after TAVI. In contrast, a systemic inflammation response shortly after TAVI was not associated with early death. Conclusions: Elevated Mon2-monocytes and a high level of monocyte activation before TAVI are associated with early mortality after TAVI. Chronic inflammation in aging patients seems to be an important risk factor after TAVI. (C) 2020 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREDICT CARDIOVASCULAR EVENTS; MONOCYTE SUBSETS; CD14++CD16+ MONOCYTES; FUNCTIONAL-CAPACITY; EXPANSION; CD16(+); COUNTS; Transcatheter aortic valve implantation (TAVI); Monocytes; Inflammation; Monocyte-platelet-aggregates (MPA); CC11b |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 12:06 |
| Last Modified: | 08 Mar 2021 12:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43496 |
Actions (login required)
 |
View Item |
