Hayek, Inaya and Schatz, Valentin and Bogdan, Christian and Jantsch, Jonathan and Luehrmann, Anja (2021) Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions. CELLULAR AND MOLECULAR LIFE SCIENCES, 78. pp. 1887-1907. ISSN 1420-682X, 1420-9071
Full text not available from this repository. (Request a copy)Abstract
Various factors of the tissue microenvironment such as the oxygen concentration influence the host-pathogen interaction. During the past decade, hypoxia-driven signaling via hypoxia-inducible factors (HIF) has emerged as an important factor that affects both the pathogen and the host. In this chapter, we will review the current knowledge of this complex interplay, with a particular emphasis given to the impact of hypoxia and HIF on the inflammatory and antimicrobial activity of myeloid cells, the bacterial responses to hypoxia and the containment of bacterial infections under oxygen-limited conditions. We will also summarize how low oxygen concentrations influence the metabolism of neutrophils, macrophages and dendritic cells. Finally, we will discuss the consequences of hypoxia and HIF alpha activation for the invading pathogen, with a focus on Pseudomonas aeruginosa, Mycobacterium tuberculosis, Coxiella burnetii, Salmonella enterica and Staphylococcus aureus. This includes a description of the mechanisms and microbial factors, which the pathogens use to sense and react to hypoxic conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCIBLE FACTOR-I; MITOCHONDRIAL CITRATE CARRIER; MYCOBACTERIUM-TUBERCULOSIS; PSEUDOMONAS-AERUGINOSA; INNATE IMMUNITY; DENDRITIC CELL; IFN-GAMMA; ANTIMICROBIAL ACTIVITY; ANTIBIOTIC-RESISTANCE; CHLAMYDIA-PNEUMONIAE; Hypoxia; HIF1α Infection; Bacteria; Metabolism; Macrophages; Neutrophils; Dendritic cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 04:58 |
| Last Modified: | 21 Apr 2021 04:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43502 |
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