Eder, Beatrix and Melter, Michael and Gabler, Vanessa and Zant, Robert and Knoppke, Birgit (2021) Risk factors associated with cognitive impairment in patients after pediatric liver transplantation. PEDIATRIC TRANSPLANTATION, 25 (2): e13879. ISSN 1397-3142, 1399-3046
Full text not available from this repository. (Request a copy)Abstract
Data on cognitive function after pLT are rare, particularly regarding children with cognitive impairment. From 2016 to 2018, we evaluated cognitive function in 36 patients after pLT aged 6-17 years with the WISC IV (at least 1 year after transplantation) and analyzed potential risk factors for cognitive impairment (IQ < 70) by means of retrospective medical data (peri-, intra-, and post-operative factors, and donor and specific organ data of the primary liver transplant) on an exploratory base. At a median age of 9.6 years (range = 6-16.9), 22% of patients were cognitive impaired (IQ < 70; including five untestable patients with severe cognitive impairment). Children tested with the WISC IV scored within the lower normal range but differed significantly from normal population. Strongest associations showed infections at pLT, development of severe sepsis requiring intensive care within the first 6 months after pLT, neurological complications within the first 10 days and the occurrence of CPR during or after pLT, and as early laboratory variables pH value on day 0 after pLT. In our analysis, neither intraoperative factors nor donor-specific factors seemed to influence cognitive outcome. In our small cohort, medical complications before and after pLT but not transplantation itself had an influence on cognitive outcome. As such, children experiencing medical problems before and in the early post-operative phase after pLT should be closely evaluated in larger samples regarding their neurological and psychomotor development during vulnerable phases and should receive early educational support to improve long-term cognitive function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACADEMIC OUTCOMES; CHILDREN; PERFORMANCE; SURVIVORS; GROWTH; UPDATE; children; cognitive function; cognitive impairment; complications; pediatric liver transplantation; WISC IV |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 04:54 |
| Last Modified: | 21 Apr 2021 04:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43509 |
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