Kopczynski, Dominik and Hentschel, Andreas and Coman, Cristina and Schebb, Nils Helge and Hornemann, Thorsten and Mashek, Douglas G. and Hartung, Nicole M. and Shevchuk, Olga and Schott, Hans-Frieder and Lorenz, Kristina and Torta, Federico and Burla, Bo and Zahedi, Rene P. and Sickmann, Albert and Kreutz, Michael R. and Ejsing, Christer S. and Medenbach, Jan and Ahrends, Robert (2020) Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics. ANALYTICAL CHEMISTRY, 92 (20). pp. 13672-13676. ISSN 0003-2700, 1520-6882
Full text not available from this repository. (Request a copy)Abstract
We introduce STAMPS, a pathway-centric web service for the development of targeted proteomics assays. STAMPS guides the user by providing several intuitive interfaces for a rapid and simplified method design. Applying our curated framework to signaling and metabolic pathways, we reduced the average assay development time by a factor of similar to 150 and revealed that the insulin signaling is actively controlled by protein abundance changes in insulin-sensitive and -resistance states. Although at the current state STAMPS primarily contains mouse data, it was designed for easy extension with additional organisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEINS; RESOURCE; SEQUENCE; UNIPROT; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 14:14 |
| Last Modified: | 08 Mar 2021 14:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43541 |
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