van Doeveren, Thomas and Nakauma-Gonzalez, Jose A. and Mason, Andrew S. and van Leenders, Geert J. L. H. and Zuiverloon, Tahlita C. M. and Zwarthoff, Ellen C. and Meijssen, Isabelle C. and van der Made, Angelique C. and van Der Heijden, Antoine G. and Hendricksen, Kees and van Rhijn, Bas W. G. and Voskuilen, Charlotte S. and van Riet, Job and Dinjens, Winand N. M. and Dubbink, Hendrikus J. and van de Werken, Harmen J. G. and Boormans, Joost L. (2021) The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder. INTERNATIONAL JOURNAL OF CANCER, 148 (4). pp. 981-987. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor-specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FREQUENCY; CANCER; bladder carcinoma; clonality; upper urinary tract carcinoma; urothelial carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2021 12:33 |
| Last Modified: | 18 May 2021 12:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43569 |
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