Schulte-Mattler, W. J. and Grimm, T. and Stein, F. and Kobor, I. and Bogdahn, U. (2015) MUNIX - A Promising Biomarker in ALS. KLINISCHE NEUROPHYSIOLOGIE, 46 (4). pp. 186-189. ISSN 1434-0275, 1439-4081
Full text not available from this repository. (Request a copy)Abstract
Motor unit number estimation (MUNE) methods are useful for monitoring the loss of anterior horn cells in patients with amyotrophic lateral sclerosis (ALS). They seem to reflect the course of the disease more sensitively than clinical scores or neurophysiological standard methods, but are much more time consuming. The latter is not the case with a recently proposed method, the measurement of the motor unit number index (MUNIX). As the underlying principle of this method is not intuitively clear, we here attempt to give a comprehensive explanation of it. Studies of MUNIX in patients with ALS have shown that MUNIX has a similar sensitivity as MUNE to monitor disease progression. Yet, it is not sufficiently clear if the MUNIX in fact reflects the number of vital anterior horn cells or if there are other factors, such as loss of upper motor neurons, have a considerable influence on the MUNIX.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; amyotrophic lateral sclerosis; motor neuron disease; biomarker; motor unit; MUNIX |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 May 2019 11:21 |
| Last Modified: | 02 May 2019 11:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4363 |
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