Pallerla, Srinivas Reddy and Harms, Dominik and Johne, Reimar and Todt, Daniel and Steinmann, Eike and Schemmerer, Mathias and Wenzel, Juergen J. and Hofmann, Joerg and Shih, James Wai Kuo and Wedemeyer, Heiner and Bock, C. -Thomas and Velavan, Thirumalaisamy P. (2020) Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health. PATHOGENS, 9 (10): 856. ISSN 2076-0817
Full text not available from this repository. (Request a copy)Abstract
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-B-HEPATITIS; TRANSMITTED NON-A; CROSS-SPECIES INFECTION; 1ST DOCUMENTED OUTBREAK; WATER-BORNE HEPATITIS; VIRAL-HEPATITIS; DISPLACED PERSONS; SEVERE HEMOLYSIS; NORTHERN UGANDA; RENAL-FAILURE; hepatitis E; infection; outbreak; epidemiology; global health |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Apr 2021 11:25 |
| Last Modified: | 20 Apr 2021 11:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43646 |
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