Frodl, Thomas and Strehl, Katharina and Carballedo, Angela and Tozzi, Leonardo and Doyle, Myles and Amico, Francesco and Gormley, John and Lavelle, Grace and O'Keane, Veronica (2020) Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly. BRAIN IMAGING AND BEHAVIOR, 14 (5). pp. 1577-1587. ISSN 1931-7557, 1931-7565
Full text not available from this repository. (Request a copy)Abstract
Exercise improves both physical and mental health and increases neurogenesis in the dendate gyrus (DG) of the hippocampus. The aim of this study was to examine whether exercising, as compared to no change in regular physical activity, would impact on hippocampal volume, and in particular the core hippocampal structures, DG and cornu ammonis (CA) subfields, and whether any changes would be moderated by age. Thirty nine previously sedentary healthy participants were randomized to either a standardized progressive aerobic exercise program or to "no change" for 16 weeks. Mental health including profile of mood states (POMS), was assessed before and every 4 weeks during the program. Magnetic resonance imaging to examine hippocampal subfields was carried out before and after the program. Aerobic exercise resulted in a significant improvement of the POMS item 'vigour' compared to those in the control group. Overall left hippocampal and left CA4-DG volumes increased significantly in the exercise group while no significant changes were seen in the control group. Older adults in the control group demonstrated significant reductions in CA4-DG subfields over the study, whereas older adults in the exercise group did not show volume decline. These findings reinforce the literature that exercise has a beneficial effect on mental health and can prevent age-related volume decline. Exercise to Improve Resilience,, NCT02541136, Rec Ref 2011/45/13.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHYSICAL-ACTIVITY; DENTATE GYRUS; BRAIN; DEPRESSION; INTERVENTION; NEUROGENESIS; MEMORY; SENSITIVITY; PLASTICITY; DURATION; Brain imaging; Hippocampus; Gyrus dendatus; Aerobic exercise; Mood; Aging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2021 07:25 |
| Last Modified: | 10 Mar 2021 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43654 |
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