Muerner-Lavanchy, Ines M. and Koenig, Julian and Ando, Ayaka and Henze, Romy and Schell, Susanne and Resch, Franz and Brunner, Romuald and Kaess, Michael (2020) Neuropsychological development in adolescents: Longitudinal associations with white matter microstructure. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, 45: 100812. ISSN 1878-9293, 1878-9307
Full text not available from this repository. (Request a copy)Abstract
Important neuropsychological changes during adolescence coincide with the maturation of white matter microstructure. Few studies have investigated the association between neuropsychological development and white matter maturation longitudinally. We aimed to characterize developmental trajectories of inhibition, planning, emotion recognition and risk-taking and examine whether white matter microstructural characteristics were associated with neuropsychological development above and beyond age. In an accelerated longitudinal cohort design, n 1/4 112 healthy adolescents between ages 9 and 16 underwent cognitive assessment and diffusion MRI over three years. Fractional anisotropy (FA) and mean diffusivity (MD) were extracted for major white matter pathways using an automatic probabilistic reconstruction technique and mixed models were used for statistical analyses. Inhibition, planning and emotion recognition performance improved linearly across adolescence. Risk-taking developed in a quadratic fashion, with stable performance between 9 and 12 and an increase between ages 12 and 16. Including cingulum and superior longitudinal fasciculus FA slightly improved model fit for emotion recognition across age. We found no evidence that FA or MD were related to inhibition, planning or risk-taking across age. Our results challenge the additional value of white matter microstructure to explain neuropsychological development in healthy adolescents, but more longitudinal research with large datasets is needed to identify the potential role of white matter microstructure in cognitive development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; AGE-RELATED-CHANGES; RISK-TAKING; INHIBITORY CONTROL; INDIVIDUAL-DIFFERENCES; EMOTION RECOGNITION; EXECUTIVE FUNCTIONS; LANGUAGE PATHWAYS; SELF-CONTROL; HUMAN BRAIN; Cognition; Adolescent; Development; Longitudinal; Diffusion tensor imaging; White matter microstructure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2021 07:31 |
| Last Modified: | 10 Mar 2021 07:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43655 |
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