Jakob, Carolin E. M. and Borgmann, Stefan and Duygu, Fazilet and Behrends, Uta and Hower, Martin and Merle, Uta and Friedrichs, Anette and Tometten, Lukas and Hanses, Frank and Jung, Norma and Rieg, Siegbert and Wille, Kai and Gruener, Beate and Klinker, Hartwig and Gersbacher-Runge, Nicole and Hellwig, Kerstin and Eberwein, Lukas and Dolff, Sebastian and Rauschning, Dominic and von Bergwelt-Baildon, Michael and Lanznaster, Julia and Strauss, Richard and Trauth, Janina and de With, Katja and Ruethrich, Maria and Lueck, Catherina and Nattermann, Jacob and Tscharntke, Lene and Pilgram, Lisa and Fuhrmann, Sandra and Classen, Annika and Stecher, Melanie and Schons, Maximilian and Spinner, Christoph and Vehreschild, Joerg Janne (2021) First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". INFECTION, 49 (1). pp. 63-73. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
Purpose Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Methods Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. Results We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42,p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74,p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81,p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50,p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72,p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69,p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. Conclusion The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEW-YORK-CITY; COVID-19; OUTCOMES; SARS-CoV-2; COVID-19; LEOSS; Cohort study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 06:56 |
| Last Modified: | 28 Feb 2022 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43712 |
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