Patasic, Lea and Seifried, Janna and Bezler, Valerie and Kaljanac, Marcell and Schneider, Irene C. and Schmitz, Heike and Tondera, Christiane and Hartmann, Jessica and Hombach, Andreas and Buchholz, Christian J. and Abken, Hinrich and Koenig, Renate and Cichutek, Klaus (2020) Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4(+)T cells to reduce the latent HIV(+)cell reservoir. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 209 (6). pp. 681-691. ISSN 0300-8584, 1432-1831
Full text not available from this repository. (Request a copy)Abstract
Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4(+)target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUICIDE-GENE; HIV ENTRY; CD4; LYMPHOCYTES; TRANSDUCTION; MECHANISM; DEPLETION; LYMPHOMA; POTENCY; BINDS; DARPin; CAR T cells; HIV reservoir; T cell therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2021 12:42 |
| Last Modified: | 11 Mar 2021 12:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43807 |
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