Rustler, Karin and Maleeva, Galyna and Gomila, Alexandre M. J. and Gorostiza, Pau and Bregestovski, Piotr and Koenig, Burkhard (2020) Optical Control of GABA(A) Receptors with a Fulgimide-Based Potentiator. CHEMISTRY-A EUROPEAN JOURNAL, 26 (56). pp. 12722-12727. ISSN 0947-6539, 1521-3765
Full text not available from this repository. (Request a copy)Abstract
Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic gamma-aminobutyric acid receptors (GABA(A)Rs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; PHARMACOLOGY; DERIVATIVES; fulgimides; GABA(A) Receptors; in vivo; photopharmacology |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2021 12:47 |
| Last Modified: | 11 Mar 2021 12:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43811 |
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