Napp, L. Christian and Cammann, Victoria L. and Jaguszewski, Milosz and Szawan, Konrad A. and Wischnewsky, Manfred and Gili, Sebastiano and Knorr, Maike and Heiner, Susanne and Citro, Rodolfo and Bossone, Eduardo and D'Ascenzo, Fabrizio and Neuhaus, Michael and Franke, Jennifer and Sorici-Barb, Ioana and Noutsias, Michel and Burgdorf, Christof and Koenig, Wolfgang and Kherad, Behrouz and Sarcon, Annahita and Rajan, Lawrence and Michels, Guido and Pfister, Roman and Cuneo, Alessandro and Jacobshagen, Claudius and Karakas, Mahir and Pott, Alexander and Meyer, Philippe and Arroja, Jose D. and Banning, Adrian and Cuculi, Florim and Kobza, Richard and Fischer, Thomas A. and Vasankari, Tuija and Airaksinen, K. E. Juhani and Hauck, Christian and Paolini, Carla and Bilato, Claudio and Imori, Yoichi and Kato, Ken and Kobayashi, Yoshio and Opolski, Grzegorz and Budnik, Monika and Dworakowski, Rafal and MacCarthy, Philip and Kaiser, Christoph and Osswald, Stefan and Galiuto, Leonarda and Dichtl, Wolfgang and Chan, Christina and Bridgman, Paul and Beug, Daniel and Delmas, Clement and Lairez, Olivier and El-Battrawy, Ibrahim and Akin, Ibrahim and Gilyarova, Ekaterina and Shilova, Alexandra and Gilyarov, Mikhail and Horowitz, John D. and Polednikova, Karolina and Tousek, Petr and Widimsky, Petr and Winchester, David E. and Galuszka, Jan and Ukena, Christian and Poglajen, Gregor and Carrilho-Ferreira, Pedro and Di Mario, Carlo and Prasad, Abhiram and Rihal, Charanjit S. and Schulze, P. Christian and Bianco, Matteo and Crea, Filippo and Borggrefe, Martin and Maier, Lars S. and Pinto, Fausto J. and Braun-Dullaeus, Ruediger C. and Rottbauer, Wolfgang and Katus, Hugo A. and Hasenfuss, Gerd and Tschoepe, Carsten and Pieske, Burkert M. and Thiele, Holger and Schunkert, Heribert and Boehm, Michael and Felix, Stephan B. and Muenzel, Thomas and Bax, Jeroen J. and Bauersachs, Johann and Braunwald, Eugene and Luescher, Thomas F. and Ruschitzka, Frank and Ghadri, Jelena R. and Templin, Christian (2020) Coexistence and outcome of coronary artery disease in Takotsubo syndrome. EUROPEAN HEART JOURNAL, 41 (34). 3255-+. ISSN 0195-668X, 1522-9645
Full text not available from this repository. (Request a copy)Abstract
Aims Takotsubo syndrome (US) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in US patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with US. Methods and results Coronary anatomy and CAD were studied in patients diagnosed with US. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 US patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non -obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with US, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort. Conclusions Coronary artery disease frequently coexists in US patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; SYNDROME TAKO-TSUBO; ST-SEGMENT ELEVATION; CARDIOMYOPATHY; PREVALENCE; TRIGGER; SCORE; 1ST; Takotsubo syndrome; Myocardial infarction; Acute coronary syndrome; Coronary artery disease; Cardiac catheterization; Outcome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2021 07:32 |
| Last Modified: | 12 Mar 2021 07:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43843 |
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