Allgaier, Raphael and Strack, Christina and Wallner, Stefan and Hubauer, Ute and Uecer, Ekrem and Lehn, Petra and Keyser, Andreas and Luchner, Andreas and Maier, Lars and Jungbauer, Carsten (2020) N-acetyl-b-D-glucosaminidase: A potential cardiorenal biomarker with a relevant impact onICDshock therapies and mortality. NEPHROLOGY, 25 (12). pp. 888-896. ISSN 1320-5358, 1440-1797
Full text not available from this repository. (Request a copy)Abstract
Aims Chronic heart failure may lead to chronic kidney disease. Previous studies suggest tubular markers N-acetyl-b-D-glucosaminidase (NAG) and Kidney-injury-molecule-1 (KIM-1) as potential markers for the cardiorenal syndrome (CRS). The prognostic value of NAG and KIM-1 regarding implantable cardioverter defibrillator (ICD) shock therapies is unknown. Methods We included 314 patients with an ICD and collected plasma and urine samples. Urine-values of NAG and KIM-1 got related to urinary creatinine. Outcomes of interest were sustained adequate shock therapies and a combined endpoint of all-cause mortality, rehospitalisation due to congestive heart failure and adequate shock therapies. Follow up time was 32 months (IQR 6-35 months). Results KIM-1 and NAG were positively correlated with NT-proBNP (KIM-1:r= .34,P < .001; NAG:r= .47,P < .001). NAG was significantly elevated in patients with primary prevention compared with secondary prevention ICD indication (P= .003). According to Kaplan Meier analysis, NAG as well as NT-proBNP were significant predictors for adequate ICD shock therapies and for the combined endpoint (eachP < .001). Elevated KIM-1 showed no significant differences (eachP= n.s.). In multivariate cox regression analysis, NAG as well as NT-proBNP were both independent predictors for adequate ICD shock therapies as well as the combined endpoint, beside ejection fraction <35% (eachP < .05). Diabetes, primary prevention ICD indication, coronary artery disease, eGFR and age were no significant predictors for both endpoints (eachP= n.s.). Conclusion Similar to NT-proBNP, NAG showed promising value for overall prognostication in ICD patients. Especially, NAG seems to incorporate an additional prognostic value regarding occurrence of ICD shock therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUDDEN CARDIAC DEATH; KIDNEY INJURY MOLECULE-1; BETA-D-GLUCOSAMINIDASE; HEART-FAILURE; RISK STRATIFICATION; TUBULAR DAMAGE; VENTRICULAR-ARRHYTHMIAS; ESC GUIDELINES; TASK-FORCE; ASSOCIATION; cardiorenal syndrome; ICD shock therapies; tubular markers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2021 07:53 |
| Last Modified: | 12 Mar 2021 07:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43849 |
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