Gottsauner, Maximilian J. and Michaelides, Ioannis and Schmidt, Barbara and Scholz, Konstantin J. and Buchalla, Wolfgang and Widbiller, Matthias and Hitzenbichler, Florian and Ettl, Tobias and Reichert, Torsten E. and Bohr, Christopher and Vielsmeier, Veronika and Cieplik, Fabian (2020) A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2. CLINICAL ORAL INVESTIGATIONS, 24 (10). pp. 3707-3713. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
Objectives SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate the effects of a 1% hydrogen peroxide mouthrinse on reducing the intraoral SARS-CoV-2 load. Methods Twelve out of 98 initially screened hospitalized SARS-CoV-2-positive patients were included in this study. Intraoral viral load was determined by RT-PCR at baseline, whereupon patients had to gargle mouth and throat with 20 mL of 1% hydrogen peroxide for 30 s. After 30 min, a second examination of intraoral viral load was performed by RT-PCR. Furthermore, virus culture was performed for specimens exhibiting viral load of at least 10(3)RNA copies/mL at baseline. Results Ten out of the 12 initially included SARS-CoV-2-positive patients completed the study. The hydrogen peroxide mouthrinse led to no significant reduction of intraoral viral load. Replicating virus could only be determined from one baseline specimen. Conclusion A 1% hydrogen peroxide mouthrinse does not reduce the intraoral viral load in SARS-CoV-2-positive subjects. However, virus culture did not yield any indication on the effects of the mouthrinse on the infectivity of the detected RNA copies. Trial registration German Clinical Trials Register (ref. DRKS00022484)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; SARS-CoV-2; COVID-19; Hydrogen peroxide; Mouthrinse; Gargle; Intraoral; Viral load |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2021 08:18 |
| Last Modified: | 12 Mar 2021 08:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43863 |
Actions (login required)
 |
View Item |
