Vill, K. and Sehri, M. and Muller, C. and Hannibal, I and Huf, V and Idriess, M. and Gerstl, L. and Bonfert, M. and Tacke, M. and Schroeder, A. S. and Landgraf, M. N. and Muller-Felber, W. and Blaschek, A. (2020) Qualitative and quantitative muscle ultrasound in patients with Duchenne muscular dystrophy: Where do sonographic changes begin? EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 28. pp. 142-150. ISSN 1090-3798, 1532-2130
Full text not available from this repository. (Request a copy)Abstract
Objective: The number of studies investigating and understanding the disease mechanisms of Duchenne muscular dystrophy (DMD) in human clinical trials have increased substantially over the last decade. Suitable clinical instruments for the measurement of disease progress and drug efficiency are mandatory, but currently not available, especially in the youngest patients. The aim of this study was to detect a reproducible pattern of muscle involvement in early stages potentially preceding evidence of motor regression. Material and methods: A cohort of 25 DMD patients aged 1-6 years at the first presentation were examined at multiple timepoints and compared with age-matched healthy controls. Muscle ultrasound was quantified using computer-analyzed gray scale levels (GSL) and blinded visual rating, using a modified Heckmatt scale. Results: Changes in muscle echogenicity in DMD patients occurred very early, clearly preceding motor regression and in some cases, even before the motor plateau phase was reached. Visual rating and GSL identified the earliest changes in the proximal adductor magnus muscle. Conclusion: Muscle ultrasound can be used as an additional method to assess the disease progression and for decision-making in paucisymptomatic DMD patients. Sonographic changes in the ad-ductor magnus muscle seem to be the first detectable changes with a recognisable pattern. (c) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NATURAL-HISTORY; DIAGNOSIS; DISEASE; MANAGEMENT; TOOL; MRI; Duchenne muscular dystrophy; Muscle ultrasound; Adductor magnus; Quantitative gray scale levels |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2021 09:19 |
| Last Modified: | 12 Mar 2021 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43882 |
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