Schebesch, Karl-Michael and Hoehne, Julius and Hohenberger, Christoph and Acerbi, Francesco and Broggi, Morgan and Proescholdt, Martin and Wendl, Christina and Riernenschneider, Markus J. and Brawanski, Alexander (2015) Fluorescein sodium-guided surgery in cerebral lymphoma. CLINICAL NEUROLOGY AND NEUROSURGERY, 139. pp. 125-128. ISSN 0303-8467, 1872-6968
Full text not available from this repository. (Request a copy)Abstract
Objectives: Growth and progress of primary central nervous lymphoma (PCNSL) severely disrupt the blood brain barrier (BBB). Such disruptions can be intraoperatively visualized by injecting fluorescein sodium (FL) and applying a YELLOW 560 nm surgical microscope filter. Here, we report a small cohort of patients with PCNSL that mimicked high grade gliomas (HGG) or cerebral metastases (CM), who had been operated on with the use of FL. Patients and methods: Retrospectively, seven patients with PCNSL were identified, who had been operated on by means of microsurgery after intravenous FL injection. The surgical reports were screened for statements on the grade of fluorescent staining in the tumor area. One representative case was chosen to show the staining under white light as well as under filtered light at different distances to the tumor area. Results: All patients had shown bright and homogenous fluorescent staining of the tumor (n=7. 100%). No adverse effects had been observed. Conclusion: Similar to patients with HGG or CM, patients with PCNSL may benefit from use of FL and the dedicated YELLOW 560 nm filter in open surgery. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY CNS LYMPHOMA; HIGH-GRADE GLIOMAS; MALIGNANT-LYMPHOMA; BRAIN; RESECTION; DIAGNOSIS; LESIONS; FUTURE; FILTER; PCNSL; Primary central nervous lymphoma; PCNSL; Fluorescein sodium; YELLOW 560 nm filter; Fluorescence-guided surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2019 07:12 |
| Last Modified: | 06 May 2019 07:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4390 |
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