Ahrenbog, Greta and Gottsauner, Maximilian and Meier, Johannes K. and Ettl, Tobias and Reichert, Torsten E. and Klingelhoeffer, Christoph (2020) Surgical treatment of advanced medication-related osteonecrosis of the jaws: Comparison of soft tissue closure techniques and evaluation of side effects. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 48 (9). pp. 896-901. ISSN 1010-5182, 1878-4119
Full text not available from this repository. (Request a copy)Abstract
The aim of the study was to evaluate the surgical outcome of patients with advanced medication-related osteonecrosis of the jaw (MRONJ) treated with different flaps for soft tissue closure. Only MRONJ stage III patients with a minimum follow-up of 6 months were included in our prospective study. The soft tissue closure techniques were: Mylohyoid Muscle Flap, Buccal Fat Flap and mucoperiosteal flap alone. Potential risk factors and surgical side effects were analyzed. Relapses occurred in 12 of 44 included cases and 38 reached mucosal integrity within the follow-up. Cases treated with the muscle or fat flap showed better results regarding the recurrence rate (p < 0.001) and soft tissue healing (p = 0.002): only 3 of 33 developed a relapse, and 31 of 33 reached mucosal integrity. The outcome was worse if MRONJ occurred at the front areas of the jaw (p = 0.025). Postoperative, the pain level was reduced significantly (p < 0.001). Partial hypoesthesia of the lip arose in 18 cases. An impairment of the long-term prosthetic rehabilitation has not been seen.Patients with MRONJ stage III undergoing surgery benefit from extensive soft tissue closure. (C) 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BISPHOSPHONATE-RELATED OSTEONECROSIS; BUCCAL FAT PAD; SURGEONS POSITION PAPER; RISK-FACTORS; AMERICAN ASSOCIATION; MANAGEMENT; FLAP; PREVENTION; MRONJ; Bisphosphonates; Mylohyoid Muscle Flap; Denosumab; Buccal Fat Flap; Surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Mar 2021 11:51 |
| Last Modified: | 15 Mar 2021 11:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43935 |
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