Einerhand, Sarah M. H. and van Gennep, Erik J. and Mertens, Laura S. and Hendricksen, Kees and Donswijk, Maarten L. and van der Poel, Henk G. and van Rhijn, Bas W. G. (2020) F-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in muscle-invasive bladder cancer. CURRENT OPINION IN UROLOGY, 30 (5). pp. 654-664. ISSN 0963-0643, 1473-6586
Full text not available from this repository. (Request a copy)Abstract
Purpose of review In this narrative review, we assessed the role of(18)F-fluoro-2-deoxy-D-glucose-positron emission tomography/CT (FDG-PET/CT) in preoperative staging and response evaluation of neoadjuvant chemotherapy in muscle-invasive bladder carcinoma (MIBC), and to assess its incremental value to contrast-enhanced (CE)CT and MRI in terms of patient management at initial diagnosis and detection of recurrence. Recent findings A literature search in PubMed yielded 46 original reports, of which 15 compared FDG-PET/CT with CECT and one with MRI. For primary tumor assessment, FDG-PET/CT proved not accurate enough (13 reports;n = 7-70). For lymph node assessment, sensitivity of FDG-PET/CT is superior to CT with comparable specificity in 19 studies (n = 15-233). For detection of distant metastases, data from eight studies (n = 43-79) suggests that FDG-PET/CT is accurate, although comparative studies are lacking. Limited evidence (four studies,n = 19-50) suggests that FDG-PET/CT is not accurate for response evaluation of neoadjuvant chemotherapy. FDG-PET/CT incited change(s) in patient management in 18-68% of patients (five reports;n = 57-103). For detection of recurrence, seven studies (n = 29-287) indicated that FDG-PET/CT is accurate. Most studies evaluated FDG-PET/CT for lymph node assessment and reported higher sensitivity than CT, with comparable specificity. FDG-PET/CT showed incremental value to CECT for recurrence and often incited change(s) in patient management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | F-18-FDG PET/CT; FDG-PET/CT; NEOADJUVANT CHEMOTHERAPY; COMPUTED-TOMOGRAPHY; RADICAL CYSTECTOMY; DIAGNOSTIC-ACCURACY; CLINICAL-VALUE; BLOOD-FLOW; CARCINOMA; RECURRENT; bladder cancer; computed tomography; fluorodeoxyglucose F18; positron emission tomography; urothelial |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2021 10:48 |
| Last Modified: | 15 Apr 2021 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43949 |
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