Putz, Franz Josef and Jung, Ernst Michael and Putz, Christina and Banas, Miriam C. and Bergler, Tobias and Vienken, Jorg and Banas, Bernhard (2020) CONTRAST-ENHANCED ULTRASONOGRAPHY AS A NOVEL METHOD FOR THE DYNAMIC VISUALIZATION OF BLOOD FLOW AND FIBER BLOCKAGE IN DIALYZERS: A FEASIBILITY STUDY. ULTRASOUND IN MEDICINE AND BIOLOGY, 46 (9). pp. 2265-2275. ISSN 0301-5629, 1879-291X
Full text not available from this repository. (Request a copy)Abstract
The capillary dialyzer represents the central element of the extracorporeal blood circuit of a therapy system for hemodialysis. The aim of this study was to assess the blood-flow characteristics of dialyzers with the help of modern ultrasound techniques. Five brand-new dialyzers (FX80 classix, Fresenius Medical Care, Bad Homburg, Germany) and five dialyzers after a dialysis session were analyzed by different ultrasound techniques to detect functional and structural changes. B-mode and Doppler techniques were not suitable to describe differences in brand-new and clinically applied dialyzers. Contrast-enhanced ultrasonography, however, was able to visualize blood-flow profiles in the capillaries. Although dialyzers displayed no signs of clinical dysfunction, contrast-enhanced ultrasonography was able to detect blocked capillaries of varying degrees after a dialysis session in all five examined dialyzers. Consequently, the blood-flow velocity was higher in the remaining unblocked capillaries in comparison to the velocity in the brand-new dialyzers. This information may be helpful for improving the geometric design of dialyzers, including their capillary membranes, and optimizing anti-coagulation strategies in hemodialysis patients. (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOCAL LIVER-LESIONS; ULTRASOUND CEUS; CLINICAL-PRACTICE; DIAGNOSTIC-ACCURACY; HEMODIALYZER; RECOMMENDATIONS; GUIDELINES; Hemodialysis; Contrast-enhanced ultrasonography (CEUS); Capillary blockage; Dialyzer; Blood flow; Time-intensity curve; Parametric; Perfusion |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Mar 2021 12:50 |
| Last Modified: | 15 Mar 2021 12:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43954 |
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