Anpilov, Sergey and Shemesh, Yair and Eren, Noa and Harony-Nicolas, Hala and Benjamin, Asaf and Dine, Julien and Oliveira, Vinicius E. M. and Forkosh, Oren and Karamihalev, Stoyo and Huettl, Rosa-Eva and Feldman, Noa and Berger, Ryan and Dagan, Avi and Chen, Gal and Neumann, Inga D. and Wagner, Shlomo and Yizhar, Ofer and Chen, Alon (2020) Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors. NEURON, 107 (4). 644-+. ISSN 0896-6273, 1097-4199
Full text not available from this repository. (Request a copy)Abstract
Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRANASAL OXYTOCIN; AGGRESSIVE-BEHAVIOR; RECEPTOR; MICE; KNOCKOUT; AMYGDALA; ANXIETY; MODELS; BRAIN; OPTOELECTRONICS; |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2021 07:22 |
| Last Modified: | 16 Mar 2021 07:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43997 |
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