Rivinius, Rasmus and Kaya, Ziya and Schramm, Rene and Boeken, Udo and Provaznik, Zdenek and Heim, Christian and Knosalla, Christoph and Schoenrath, Felix and Rieth, Andreas and Berchtold-Herz, Michael and Barten, Markus J. and Rauschning, Dominic and Muecke, Victoria T. and Heyl, Stephan and Pistulli, Rudin and Grinninger, Carola and Hagl, Christian and Gummert, Jan F. and Warnecke, Gregor and Schulze, P. Christian and Katus, Hugo A. and Kreusser, Michael M. and Raake, Philip W. (2020) COVID-19 among heart transplant recipients in Germany: a multicenter survey. CLINICAL RESEARCH IN CARDIOLOGY, 109 (12). pp. 1531-1539. ISSN 1861-0684, 1861-0692
Full text not available from this repository. (Request a copy)Abstract
Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted a nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics of heart transplant recipients with COVID-19 during the first months of the pandemic in Germany. Methods and results A multicenter survey of all heart transplant centers in Germany evaluating the current status of COVID-19 among adult heart transplant recipients was performed. A total of 21 heart transplant patients with COVID-19 was reported to the transplant centers during the first months of the pandemic in Germany. Mean patient age was 58.6 +/- 12.3 years and 81.0% were male. Comorbidities included arterial hypertension (71.4%), dyslipidemia (71.4%), diabetes mellitus (33.3%), chronic kidney failure requiring dialysis (28.6%) and chronic-obstructive lung disease/asthma (19.0%). Most patients received an immunosuppressive drug regimen consisting of a calcineurin inhibitor (71.4%), mycophenolate mofetil (85.7%) and steroids (71.4%). Eight of 21 patients (38.1%) displayed a severe course needing invasive mechanical ventilation. Those patients showed a high mortality (87.5%) which was associated with right ventricular dysfunction (62.5% vs. 7.7%;p = 0.014), arrhythmias (50.0% vs. none;p = 0.012), and thromboembolic events (50.0% vs. none;p = 0.012). Elevated high-sensitivity cardiac troponin T- and N-terminal prohormone of brain natriuretic peptide were significantly associated with the severe form of COVID-19 (p = 0.017 andp < 0.001, respectively). Conclusion Severe course of COVID-19 was frequent in heart transplanted patients. High mortality was associated with right ventricular dysfunction, arrhythmias, thromboembolic events, and markedly elevated cardiac biomarkers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REPLICATION; SENSITIVITY; FAILURE; COV; COVID-19; Heart transplantation; Immunosuppression; Mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2021 08:43 |
| Last Modified: | 16 Mar 2021 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44032 |
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