Spoerl, Steffen and Gerken, Michael and Mamilos, Andreas and Fischer, Rene and Wolf, Stefanie and Nieberle, Felix and Klingelhoeffer, Christoph and Meier, Johannes K. and Spoerl, Silvia and Ettl, Tobias and Reichert, Torsten E. and Spanier, Gerrit (2021) Lymph node ratio as a predictor for outcome in oral squamous cell carcinoma: a multicenter population-based cohort study. CLINICAL ORAL INVESTIGATIONS, 25. pp. 1705-1713. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
Objectives Recently, multiple studies addressed the importance of lymph node ratio (LNR) in specifying patients' risk of disease recurrence in various malignancies. The present study examines the prognostic significance of LNR in predicting outcome of oral squamous cell carcinoma (OSCC) patients after surgical treatment with curative intent. Methods Here, we describe a retrospective population-based cohort with 717 patients previously diagnosed with OSCC. Histopathologically verified lymph node metastasis was diagnosed in 290 patients. Among these patients, we evaluated the impact of LNR on overall survival (OAS) and recurrence-free survival (RFS) in uni- as well as multivariate analysis. Results A median cutoff (0.055) in LNR was found to significantly predict outcome in OSCC patients. Five-year OAS was 54.1% in patients with a low LNR, whereas a high LNR was associated with a 5-year OAS of 33.3% (p< 0.001). Similar results were detected for RFS with a 5-year survival rate of 49.8% (LNR low) and 30.3% (LNR high) (p = 0.002). Results were confirmed in multivariate Cox regression which substantiated the importance of LNR in predicting survival in OSCC patients. Conclusions LNR was shown to be an independent prognostic factor for outcome of OSCC in a population-based cohort in uni- as well as multivariate analysis. Hereby, a LNR >= 0.055 predicted a shorter OAS and RFS in our cohort.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGNOSTIC VALUE; POSITIVE NODES; 8TH EDITION; HEAD; CANCER; DENSITY; CAVITY; CHEMOTHERAPY; METASTASIS; SURVIVAL; Oral squamous cell carcinoma; Lymph node ratio; Lymph node density; Survival; Recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2021 07:57 |
| Last Modified: | 15 Apr 2021 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44057 |
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