Cederroth, Christopher R. and Lugo, Alessandra and Edvall, Niklas K. and Lazar, Andra and Lopez-Escamez, Jose-Antonio and Bulla, Jan and Uhlen, Inger and Hoare, Derek J. and Baguley, David M. and Canlon, Barbara and Gallus, Silvano (2020) Association between Hyperacusis and Tinnitus. JOURNAL OF CLINICAL MEDICINE, 9 (8): 2412. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18-90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n= 1388) or without (n= 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99-4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06-10.9), and THI >= 58 (OR 12.1, 95% CI 7.06-20.6). The association with THI >= 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68-14.2) for moderate and 77.4 (95% CI 35.0-171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; FUNCTIONAL INDEX DEVELOPMENT; DEPRESSION; ANXIETY; PROFILE; tinnitus; hyperacusis; TMJ; headache; migraine; hearing loss; subtype; somatosensory |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Mar 2021 09:51 |
| Last Modified: | 17 Mar 2021 09:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44085 |
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