Arens, Jutta and Grottke, Oliver and Haverich, Axel and Maier, Lars S. and Schmitz-Rode, Thomas and Steinseifer, Ulrich and Wendel, H. P. and Rossaint, Rolf (2020) Toward a Long-Term Artificial Lung. ASAIO JOURNAL, 66 (8). pp. 847-854. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Only a very small portion of end-stage organ failures can be treated by transplantation because of the shortage of donor organs. Although artificial long-term organ support such as ventricular assist devices provide therapeutic options serving as a bridge-to-transplantation or destination therapy for end-stage heart failure, suitable long-term artificial lung systems are still at an early stage of development. Although a short-term use of an extracorporeal lung support is feasible today, the currently available technical solutions do not permit the long-term use of lung replacement systems in terms of an implantable artificial lung. This is currently limited by a variety of factors: biocompatibility problems lead to clot formation within the system, especially in areas with unphysiological flow conditions. In addition, proteins, cells, and fibrin are deposited on the membranes, decreasing gas exchange performance and thus, limiting long-term use. Coordinated basic and translational scientific research to solve these problems is therefore necessary to enable the long-term use and implantation of an artificial lung. Strategies for improving the biocompatibility of foreign surfaces, for new anticoagulation regimes, for optimization of gas and blood flow, and for miniaturization of these systems must be found. These strategies must be validated byin vitroandin vivotests, which remain to be developed. In addition, the influence of long-term support on the pathophysiology must be considered. These challenges require well-connected interdisciplinary teams from the natural and material sciences, engineering, and medicine, which take the necessary steps toward the development of an artificial implantable lung.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACORPOREAL MEMBRANE-OXYGENATION; NITRIC-OXIDE; PEDIATRIC OXYGENATOR; AUTOMATIC-CONTROL; FIBER BUNDLE; BLOOD-FLOW; MODEL; HEPARIN; HEMOCOMPATIBILITY; BRIDGE; artificial lung; ECMO; lung assist; lung support; implantable artificial lung; biocompatibility; anticoagulation regimes; in silicoanalysis; in vitroverification; in vivovalidation; miniaturization; structural integration; hemocompatibility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 08:36 |
| Last Modified: | 14 Apr 2021 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44106 |
Actions (login required)
 |
View Item |
