Birkenmaier, Clemens and Dornia, Christian and Lehle, Karla and Mueller, Thomas and Gruber, Michael and Philipp, Alois and Krenkel, Lars (2020) Analysis of Thrombotic Deposits in Extracorporeal Membrane Oxygenators by High-resolution Microcomputed Tomography: A Feasibility Study. ASAIO JOURNAL, 66 (8). pp. 922-928. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Coagulative disorders, especially clotting during extracorporeal membrane oxygenation, are frequent complications. Direct visualization and analysis of deposits in membrane oxygenators using computed tomography (CT) may provide an insight into the underlying mechanisms causing thrombotic events. However, the already established multidetector CT1(MDCT) method shows major limitations. Here, we demonstrate the feasibility of applying industrial micro-CT (mu CT) to circumvent these restrictions. Three clinically used membrane oxygenators were investigated applying both MDCT and mu CT. The scans were analyzed in terms of clot volume and local clot distribution. As validation, the clot volume was also determined from the fluid volume, which could be filled into the respective used oxygenator compared to a new device. In addition, cross-sectional CT images were compared with crosscut oxygenators. Based on the mu CT findings, a morphological measure (sphericity) for assessing clot structures in membrane oxygenators is introduced. Furthermore, by comparing MDCT and mu CT results, an augmentation of the MDCT method is proposed, which allows for improved clot volume determination in a clinical setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VOLUME; computed tomography; micro-CT; clot detection; thrombotic deposits; extracorporeal membrane oxygenation; membrane lung |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Mar 2021 12:03 |
| Last Modified: | 17 Mar 2021 12:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44107 |
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