Aziz, Atiqullah and Gierth, Michael and Rink, Michael and Schmid, Marianne and Chun, Felix K. and Dahlem, Roland and Roghmann, Florian and Palisaar, Rein-Jueri and Noldus, Joachim and Ellinger, Joerg and Mueller, Stefan C. and Pycha, Armin and Martini, Thomas and Bolenz, Christian and Moritz, Rudolf and Herrmann, Edwin and Keck, Bastian and Wullich, Bernd and Mayr, Roman and Fritsche, Hans-Martin and Burger, Maximilian and Bastian, Patrick J. and Seitz, Christian and Brookman-May, Sabine and Xylinas, Evanguelos and Shariat, Shahrokh F. and Fisch, Margit and May, Matthias (2015) Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta. WORLD JOURNAL OF UROLOGY, 33 (12). pp. 1945-1950. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
Radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB) is associated with heterogeneous functional and oncological outcomes. The aim of this study was to generate trifecta and pentafecta criteria to optimize outcome reporting after RC. We interviewed 50 experts to consider a virtual group of patients (age a parts per thousand currency sign 75 years, ASA score a parts per thousand currency sign 3) undergoing RC for a cT2 UCB and a final histology of a parts per thousand currency signpT3pN0M0. A ranking was generated for the three and five criteria with the highest sum score. The criteria were applied to the Prospective Multicenter Radical Cystectomy Series 2011. Multivariable binary logistic regression analyses were used to evaluate the impact of clinical and histopathological parameters on meeting the top selected criteria. The criteria with the highest sum score were negative soft tissue surgical margin, lymph node (LN) dissection of at least 16 LNs, no complications according to Clavien-Dindo grade 3-5 within 90 days after RC, treatment-free time between TUR-BT with detection of muscle-invasive UCB and RC < 3 months and the absence of local UCB-recurrence in the pelvis a parts per thousand currency sign12 months. The first three criteria formed trifecta, and all five criteria pentafecta. A total of 334 patients qualified for final analysis, whereas 35.3 and 29 % met trifecta and pentafecta criteria, respectively. Multivariable analyses showed that the relative probability of meeting trifecta and pentafecta decreases with higher age (3.2 %, p = 0.043 and 3.3 %, p = 0.042) per year, respectively. Trifecta and pentafecta incorporate essential criteria in terms of outcome reporting and might be considered for the improvement of standardized quality assessment after RC for UCB.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; LOCOREGIONAL FAILURE; CONTEMPORARY SERIES; CANCER; COMPLICATIONS; MORTALITY; Urothelial carcinoma; Radical cystectomy; Outcome; Trifecta; Pentafecta |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2019 07:21 |
| Last Modified: | 06 May 2019 07:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4411 |
Actions (login required)
 |
View Item |
