Kornhuber, Johannes and Zoicas, Iulia (2020) Social Fear Memory Requires Two Stages of Protein Synthesis in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (15): 5537. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
It is well known that long-term consolidation of newly acquired information, including information related to social fear, require de novo protein synthesis. However, the temporal dynamics of protein synthesis during the consolidation of social fear memories is unclear. To address this question, mice received a single systemic injection with the protein synthesis inhibitor, anisomycin, at different time-points before or after social fear conditioning (SFC), and memory was assessed 24 h later. We showed that anisomycin impaired the consolidation of social fear memories in a time-point-dependent manner. Mice that received anisomycin 20 min before, immediately after, 6 h, or 8 h after SFC showed reduced expression of social fear, indicating impaired social fear memory, whereas anisomycin caused no effects when administered 4 h after SFC. These results suggest that consolidation of social fear memories requires two stages of protein synthesis: (1) an initial stage starting during or immediately after SFC, and (2) a second stage starting around 6 h after SFC and lasting for at least 5 h.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANISOMYCIN-INDUCED AMNESIA; CONDITIONED DEFEAT; SYNTHESIS INHIBITION; TIME WINDOWS; CONSOLIDATION; AVOIDANCE; AMYGDALA; PERIODS; KINASE; HIPPOCAMPUS; social fear; social anxiety; anisomycin; protein synthesis; social investigation; fear learning; fear acquisition; fear extinction; fear memory; memory consolidation |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Mar 2021 10:44 |
| Last Modified: | 17 Mar 2021 10:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44114 |
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