Wolff, Daniel and Herzberg, Philipp Y. and Herrmann, Anne and Pavletic, Steven Z. and Heussner, Pia and Mumm, Friederike and Hoefer, Christina and Hilgendorf, Inken and Hemmati, Philipp G. and Holler, Ernst and Greinix, Hildegard and Mitchell, Sandra A. (2021) Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease-results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health. BONE MARROW TRANSPLANTATION, 56 (1). pp. 243-256. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL within a multicenter trial, including 208 patients (pts) after alloHSCT, who were prospectively evaluated applying the FACT-BMT, the Human Activity Profile (HAP), the SF-36 v.2, PTMI and the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI). The most prevalent comorbidities were compensated arterial hypertension (28.4%), ambulatory infections (25.5%), iron overload (23%), mild renal function impairment (20%), and osteoporosis (13%). Applying the PTMI 13% of patients had no comorbidity, while 37.1% had 1-3 comorbidities, 27.4% had 4-6 comorbidities, and 13.5% had > 6 comorbidities. Chronic graft-versus-host disease (cGvHD) was significantly associated with the PTMI, while age and prior acute GvHD were not. In contrast, the HCT-CI was not associated with the presence of cGvHD. cGvHD was significantly associated with depression (r = 0.16), neurological disease (r = 0.21), osteoporosis (r = 0.18) and nonmelanoma skin cancer (r = 0.26). The PTMI demonstrated strong measurement properties and compared to the HCT-CI captured a wider range of comorbidities associated with cGvHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPOIETIC-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; BONE-MARROW-TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; COMORBIDITY INDEX; CLINICAL-PRACTICE; ALLOGENEIC TRANSPLANTATION; INTERNATIONAL-BLOOD; FUNCTIONAL STATUS; APLASTIC-ANEMIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 05:58 |
| Last Modified: | 28 Feb 2022 05:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44139 |
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