Roman, Celia and Egert, Luisa and Di Benedetto, Barbara (2020) Astrocytic-neuronal crosstalk gets jammed: Alternative perspectives on the onset of neuropsychiatric disorders. EUROPEAN JOURNAL OF NEUROSCIENCE: e14900. ISSN 0953-816X, 1460-9568
Full text not available from this repository. (Request a copy)Abstract
Investigating interactions of glia cells and synapses during development and in adulthood is the focus of several research programmes which aim at understanding the neurobiology of brain physiological and pathological processes. Both glia-specific released and membrane-bound proteins play essential roles in the development, maintenance and functionality of synaptic connections. Alterations in synaptic contacts in specific brain areas are hallmarks of several brain diseases, such as major depressive disorder, autism spectrum disorder and schizophrenia. Thus, a deeper knowledge about putative astrocyte dysfunctions which might affect the synaptic compartment is warranted to improve treatment options. Here, we present the latest advances about the role of glia cells in orchestrating the arrangement of synapses and neuronal networks in physiological and pathological states. We specifically focus on the role of astrocytes in the phagocytosis of neuronal synapses as a novel mechanism which drives the refinement of neuronal circuits and might be affected in pathological conditions. Finally, we propose this astrocyte-dependent mechanism as a putative alternative target of pharmacological interventions for the treatment of brain disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENGULFMENT RECEPTOR DRAPER; CELL CORPSE ENGULFMENT; PREFRONTAL CORTEX; D-SERINE; SYNAPTIC PLASTICITY; CNS SYNAPTOGENESIS; POSTMORTEM BRAIN; SCHIZOPHRENIA; GLIA; DEPRESSION; astrocytes; neuropsychiatric disorders; pruning; synapse remodelling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 08:22 |
| Last Modified: | 14 Apr 2021 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44152 |
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